TY - CHAP M1 - Book, Section TI - Prophylactic Gastrectomy For Inherited Gastric Cancer A1 - Poultsides, George A. A1 - Norton, Jeffrey A. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Gastric cancer is the fourth most common malignancy worldwide and the second most common cause of cancer-related death.1 Histologically, gastric cancer may be classified as either of the diffuse type or of the intestinal type. The intestinal type is linked to environmental risk factors and advanced age. The diffuse type (typically associated with signet ring cell histology and/or the clinical picture of linitis plastica in advanced stages) occurs in younger patients and can have a hereditary component. Partly due to a significant decrease in the incidence of the more common intestinal type, the overall incidence of gastric cancer has decreased. However, the incidence of diffuse gastric cancer has either increased or remained stable. Approximately 10% of gastric cancer cases demonstrate familial clustering, and 1% to 3% meet the criteria for hereditary diffuse gastric cancer (HDGC).2,3 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/13 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145761811 ER -