TY - CHAP M1 - Book, Section TI - Tumors of the Salivary Glands A1 - Sandulache, Vlad C. A1 - Skinner, Heath D. A1 - Kupferman, Michael E. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Salivary gland (SG) tumors are rare neoplasms of the neck and head which can occur in the paired major salivary glands or in one of the hundreds of minor salivary glands distributed throughout the oral cavity and pharynx. Benign neoplasms are slow growing, amenable to surgical cure, and if appropriately excised recur with a low frequency. Malignant tumors can arise from any one of the cellular components of the SG. They are generally faster growing compared to their benign counterparts and often invade into adjacent structures. A subset of malignant tumors display substantial predilection for nerve invasion which can lead to increased patient morbidity and a lower rate of surgical cure. For high-grade histologies clinical outcomes remain poor and multimodality treatment strategies are employed at most centers.1-5 Due to the rarity of each specific malignant histology, there is a dearth of prospective clinical trial data, which limits our understanding of disease progression and the effects of specific surgical and nonsurgical interventions. A more detailed molecular characterization of SG cancers may shed additional light on the pathogenesis of this disease process and provide novel therapeutic interventions in the future. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145759170 ER -