TY - CHAP M1 - Book, Section TI - Gastrinoma A1 - Sorensen, Meredith J. A1 - Gauger, Paul G. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Gastrinomas are gastrin-secreting neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that result in hypergastrinemia. This leads to excessive gastric acid secretion and the resultant clinical manifestations, such as refractory PUD (with sequelae like bleeding, perforation, and obstruction), gastroesophageal reflux disease, and diarrhea.1,2 Gastrinomas are associated with multiple endocrine neoplasia type 1 (MEN-1) in about 25% of cases and occur sporadically the other three-quarters of the time.2,3 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/12 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145758331 ER -