TY - CHAP M1 - Book, Section TI - Locally Advanced and Aggressive Thyroid Cancer A1 - Noureldine, Salem I. A1 - Tufano, Ralph P. A2 - Morita, Shane Y. A2 - Balch, Charles M. A2 - Klimberg, V. Suzanne A2 - Pawlik, Timothy M. A2 - Posner, Mitchell C. A2 - Tanabe, Kenneth K. PY - 2018 T2 - Textbook of Complex General Surgical Oncology AB - Thyroid cancer is considered to be the most common endocrine malignancy, with estimated new cases exceeding 60,000 in 2013.1 Although most patients who present with thyroid cancer have well-differentiated intrathyroidal tumors that carry an excellent prognosis, these tumors have a distinct tendency for multifocal involvement and regional lymph node metastasis. The adverse prognostic factors in thyroid cancer have been well-established and include patient age, tumor histology, primary tumor size, extrathyroidal extension, and distant metastasis.2 The greatest negative impact on prognosis, from a surgical standpoint, is extrathyroidal extension.3 Up to 15% of patients with differentiated thyroid cancer (DTC) exhibit aggressive behavior, hallmarked by extrathyroidal extension, treatment resistance, and increased mortality.3,4 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/10 UR - accesssurgery.mhmedical.com/content.aspx?aid=1145757305 ER -