TY - CHAP M1 - Book, Section TI - Tissue Engineering for Cardiac Valve Surgery A1 - Gottlieb, Danielle A1 - Mayer, John E. A2 - Cohn, Lawrence H. A2 - Adams, David H. PY - 2017 T2 - Cardiac Surgery in the Adult, 5e AB - Tissue engineering is a developing science, comprising elements of engineering and biology, whose aim is to build replacement tissues de novo, from individual cellular and structural components. The impetus for our work on tissue-engineered cardiovascular structures arises from the need to replace cardiovascular tissues that failed to develop normally during embryogenesis or have become dysfunctional as a consequence of disease. In pediatric patients, the cardiovascular structures most often afflicted by congenital anomalies involve the cardiac valves and great vessels, and the theoretical advantages of a tissue-engineered structure containing live cells are the ability to grow, remodel, and repair. Although growth potential is not a consideration for the adult population, durability of valve structures remains an important issue for bioprosthetic valves, and a tissue engineering approach offers the potential to improve durability by providing the repair and remodeling capability. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1144168711 ER -