TY - CHAP M1 - Book, Section TI - Genomics and Acute Care Surgery A1 - Thompson, Callie M. A1 - O’Keefe, Grant E. A2 - Moore, Ernest E. A2 - Feliciano, David V. A2 - Mattox, Kenneth L. PY - 2017 T2 - Trauma, 8e AB - Outcomes after traumatic injury, perhaps more than in any other surgical disease, have improved through standardization of care. Nevertheless and despite seemingly ideal care, unexpected outcomes occur. Why do patients with similar injuries or severity of acute illness, despite receiving comparable and appropriate treatment, often follow different paths? While one patient recovers uneventfully from massive transfusion for hemorrhagic shock after a motor vehicle collision, another follows a prolonged course complicated by nosocomial pneumonia and organ failure. Consider also, the seemingly more straightforward task of preventing or treating deep venous thromboembolic disease. Despite our understanding of the biology of coagulation and pharmacotherapeutic strategies, venous thromboses and pulmonary emboli still occur, often with fatal consequences. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesssurgery.mhmedical.com/content.aspx?aid=1141191765 ER -