Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + TEST TAKING TIPS Download Section PDF Listen +++ ++ Test Taking Tips Manifestations of trace element deficiencies (eg, chromium, zinc, copper, etc) tend to be a recurring theme on the test. Know the basics of TPN. Learn the indications, content, and adverse effects. Do not confuse the ECG findings associated with various electrolyte abnormalities. + FLUIDS Download Section PDF Listen +++ +++ Name the 2 major body fluid compartments: ++ Intracellular and extracellular +++ Extracellular fluid is divided into these 2 subcompartments: ++ Interstitial fluid and intravascular fluid +++ Mnemonic for the composition of body fluid: ++ 60, 40, 20; 60% total body weight fluid, 40% total body weight intracellular, 20% total body weight extracellular +++ Approximate percentage of body weight that is fluid: ++ 60% +++ Approximate percentage of body fluid that is extracellular: ++ 33% +++ Approximate percentage of body weight that is intracellular: ++ 66% +++ Percentage of extracellular fluid within the vascular compartment in the venous system: ++ 85% +++ Percentage of extracellular fluid within the vascular compartment in the arterial system: ++ 15% +++ The approximate percentage of body weight that blood accounts for in an adult: ++ 7% (so to estimate how many liters of blood in a 70-kg man; 0.07 × 70 kg = 5 liters) +++ Requirement of water per 24-hour period: ++ ~30 to 35 mL/kg ++ FIGURE 7-1. Chemical composition of body fluid compartments. (Reproduced form Brunicardi FC, Anderson DK, Billiar TR, et al. Schwartz's Principles of Surgery. 9th ed. http://www.accessmedicine.com. Copyright © The McGraw-Hill Companies, Inc. All rights reserved.) Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ Requirement of sodium per 24-hour period: ++ ~1 to 2 mEq/kg +++ Requirement of chloride per 24-hour period: ++ ~1.5 mEq/kg +++ Requirement of potassium per 24-hour period: ++ ~1 mEq/kg +++ Name the sources and the amount of normal daily water loss: ++ Respiratory losses: 500 to 700 cc Sweat: 200 to 400 cc Urine: 1200 to 1500 cc Feces: 100 to 200 cc +++ Name the sources and the amount of insensible fluid loss: ++ Skin: ~300 cc/24 h Breathing: 500 to 700 cc/24 h Feces: 100 to 200 cc/24 h +++ General rate of fluid loss during an open abdominal procedure in the absence of measurable blood loss: ++ 0.5 to 1.0 L/h +++ Name the sources and the amount of normal daily electrolyte loss: ++ Chloride: 150 mEq, sodium: 100 mEq, potassium: 100 mEq +++ Name the sources and the amount of daily secretions: ++ Saliva: ~1500 cc/24 h Gastric: ~2000 cc/24 h Small intestine: ~3000 cc/24 h Bile: ~1000 cc/24 h Pancreatic: ~600 cc/24 h +++ State the electrolyte composition of sweat: ++ 30 to 50 mEq sodium, 5 mEq potassium, 45 to 55 mEq hydrogen +++ State the electrolyte composition of gastric secretions: ++ 40 to 65 mEq sodium, 90 mEq hydrogen, 100 to 140 mEq chloride +++ State the electrolyte composition of biliary secretions: ++ 135 to 155 mEq sodium, 5 mEq potassium, 80 to 110 mEq chloride, 70 to 90 mEq bicarbonate +++ State the electrolyte composition of pancreatic secretions: ++ 135 to 155 mEq sodium, 5 mEq potassium, 55 to 75 mEq chloride, 70 to 90 mEq bicarbonate +++ State the electrolyte composition of ileostomy output: ++ 120 to 130 mEq sodium, 10 mEq potassium, 50 to 60 mEq chloride, 50 to 70 mEq bicarbonate +++ State the electrolyte composition of diarrhea: ++ 25 to 50 mEq sodium, 35 to 60 mEq potassium, 20 to 40 mEq chloride, 30 to 45 mEq bicarbonate +++ Define the "third space." ++ Fluid accumulation in the interstitium of tissues (first 2 spaces: intravascular and intracellular) +++ When does third-spaced fluid tend to mobilize back into the intravascular space? ++ Postoperative day #3 +++ What is the earliest sign of volume excess during the postoperative period? ++ Weight gain +++ Classic finding with overaggressive nasogastric tube suctioning or long-standing vomiting: ++ Hypokalemic hypochloremic metabolic alkalosis +++ Name the various mechanisms that loop diuretics employ to decrease pulmonary edema: ++ Inhibit active sodium absorption in the thick ascending loop of Henle, increase venous capacitance, stimulate vasodilatory prostaglandins leading to increased renal blood flow +++ Formula to calculate serum osmolality: ++ 2 × sodium + urea/2.8 + glucose/18 +++ How much sodium and chloride are in normal saline? ++ 154 mEq Na+ and 154 mEq Cl– +++ Composition of lactated Ringer's: ++ 130 mEq Na+, 109 mEq Cl–, 4 mEq K+, 28 mEq lactate, and 3 mEq calcium +++ How many grams of dextrose in a liter of D5W? ++ 50 g; D5W is a 5% solution of dextrose (5 g dextrose/100 cc × 1000 cc/1 L = 50 g dextrose) +++ The 2 "rules" for the calculation of maintenance fluids: ++ 100/50/20 rule and 4/2/1 rule; for both rules cc/kg for first 10 kg/cc/kg for next 10 kg/cc/kg for every kg >20 kg +++ Name the standard maintenance fluid used in an adult: ++ D5 1/2 normal saline (NS) with 20 mEq KCl +++ Name the standard maintenance fluid used in a pediatric patient: ++ D5 1/4 NS with 20 mEq KCl +++ Usual minimal urine output for an adult: ++ ~30 mL/h or 0.5 mL/kg/h +++ How much of a 1-L NS bolus will stay intravascular in a 5-hour period? ++ ~200 cc or 20% + ELECTROLYTES Download Section PDF Listen +++ +++ Normal range for sodium: ++ 135 to 145 mEq/L +++ Define pseudohyponatremia and list causes: ++ Spuriously low lab result for sodium; hyperglycemia, hyperlipidemia, hyperproteinemia +++ Name the 3 types of hyponatremia: ++ Hypovolemic, euvolemic, hypervolemic +++ Name surgical causes of hypovolemic hyponatremia: ++ Burns, diaphoresis, diuretics, hypoaldosteronism, NG suctioning, pancreatitis, vomiting +++ Name surgical causes of euvolemic hyponatremia: ++ CNS abnormalities, drugs, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) +++ Name surgical causes of hypervolemic hyponatremia: ++ Congestive heart failure, cirrhosis, iatrogenic, renal failure +++ Signs and symptoms of hyponatremia: ++ Coma/confusion, ileus, lethargy, nausea/vomiting, seizure, weakness +++ Treatment of hypovolemic hyponatremia: ++ Correct the underlying cause, give IV NS +++ Treatment of euvolemic hyponatremia (SIADH): ++ Acute treatment with furosemide and normal saline; fluid restriction +++ Treatment of hypervolemic hyponatremia (dilutional): ++ Fluid restriction and diuretics +++ Grave consequence of correcting hyponatremia too quickly: ++ Myelinolysis (formerly known as central pontine myelinolysis) +++ Formula to calculate the sodium deficit: ++ (normal sodium concentration – observed sodium concentration) × total body water; Remember: total body water = 0.6 × weight (kg) +++ Approximately how much does the apparent serum sodium concentration fall for each 100 mg/dL rise in blood glucose level above normal? ++ 1.6 to 3.0 mEq/L +++ Maximal rate of sodium correction for acute hyponatremia: ++ 1 to 2 mEq/L/h for 3 to 4 hours until neurologic symptoms subside or until plasma Na is >120 mEq/L +++ Maximal rate of sodium correction for chronic hyponatremia: ++ 0.5 to 1 mEq/L/h or no faster than 10 to 12 mEq/L in the first 24 hours and 18 mEq/L in the first 48 hours +++ Name surgical causes of hypernatremia: ++ Dehydration, diabetes insipidus, diaphoresis, diarrhea, diuresis, iatrogenic, vomiting +++ Signs and symptoms of hypernatremia: ++ Confusion, peripheral/pulmonary edema, respiratory paralysis, stupor, seizures, tremors +++ Treatment of hypernatremia: ++ Slow supplementation of 1/4 NS or 1/2 NS over days +++ Formula to calculate the free water deficit: ++ Total free water deficit = 0.6 × weight (kg) × [(Serum Na+/140) – 1] +++ What is the normal range for potassium: ++ 3.5 to 5.0 mEq/L +++ Critical values for potassium: ++ K+ <2.8 mEq/L or >6.0 mEq/L +++ Name some surgical causes of hypokalemia: ++ Alkalosis, diuretics, drugs (steroids/antibiotics), diarrhea, iatrogenic, insulin, intestinal fistula, NG suctioning, vomiting +++ Signs and symptoms of hypokalemia: ++ Ileus, weakness, tetany, nausea/vomiting, paresthesia +++ EKG findings of hypokalemia: ++ Flattened T waves, U waves, ST segment depression, atrial fibrillation, premature atrial complexes/premature ventricular complexes +++ Acute treatment for hypokalemia: ++ IV KCl +++ Maximum amount of potassium that can be administered through a peripheral IV: ++ 10 mEq/h ++ FIGURE 7-2. Evaluation of sodium abnormalities. ADH, antidiuretic hormone; SIADH, syndrome of inappropriate secretion of antidiuretic hormone. (Reproduced form Brunicardi FC, Anderson DK, Billiar TR, et al. Schwartz's Principles of Surgery. 9th ed. http://www.accessmedicine.com. Copyright © The McGraw-Hill Companies, Inc. All rights reserved.) Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ Maximum amount of potassium that can be administered through a central line: ++ 20 mEq/h +++ Most common cause for an electrolyte mediated ileus in a surgical patient: ++ Hypokalemia +++ Digitalis toxicity is worsened by this electrolyte condition: ++ Hypokalemia +++ Name surgical causes of hyperkalemia: ++ Iatrogenic, diuretics, acidosis, trauma, hemolysis, renal failure, blood transfusion +++ Signs and symptoms of hyperkalemia: ++ Areflexia or decreased deep tendon reflexes, paresthesia, paralysis, weakness, and respiratory failure +++ EKG findings of hyperkalemia: ++ Peaked T waves, prolonged PR, wide QRS, depressed ST segment, ventricular fibrillation, bradycardia +++ What is the treatment for hyperkalemia? ++ IV calcium, sodium bicarbonate, dextrose and insulin (1 amp 50% dextrose and 10 U insulin), albuterol, kayexalate, furosemide, dialysis +++ Most of the calcium in the body is contained within: ++ Bone +++ Percentage of serum calcium that is nonionized and bound to plasma protein: ++ ~50% +++ Percentage of serum calcium that is nonionized and bound to substances other than plasma protein in the plasma: ++ 5% +++ How much does a 1-g drop in protein decrease the measured total serum calcium? ++ 0.8 mg/dL +++ In the setting of rapid transfusion, how much calcium should be given per 500 cc of transfused blood? ++ 0.2 g/500 cc transfused blood +++ Name some surgical causes of hypocalcemia: ++ Acute pancreatitis, aminoglycosides, diuretics, hypomagnesemia, intestinal bypass, osteoblastic metastasis, renal failure, rhabdomyolysis, sepsis, short bowel syndrome, vitamin D deficiency +++ Formula to determine the calcium level with hypoalbuminemia: ++ Serum calcium + [(4 – measured albumin) × 0.8] +++ Signs and symptoms of hypocalcemia: ++ Abdominal cramping, Chvostek signs, confusion, depression, hallucinations, increased deep tendon reflexes, laryngospasm, paranoia, perioral paresthesia, seizures, stridor, tetany, Trousseau sign +++ Define Chvostek sign: ++ Tapping of facial nerve with resultant facial muscle spasm +++ Define Trousseau sign: ++ Utilization of a blood pressure cuff to occlude blood flow to the forearm with resultant latent tetany evidenced by carpal spasm +++ EKG findings hypocalcemia: ++ Peaked T waves, prolonged QT and ST intervals +++ Acute treatment of hypocalcemia: ++ IV calcium supplementation +++ Chronic treatment of hypocalcemia: ++ PO calcium and vitamin D supplementation +++ Mnemonic for hypercalcemia: ++ Chimpanzees: Calcium supplementation, hyperparathyroidism (primary/tertiary)/hyperthyroidism, iatrogenic/immobility, milk alkali syndrome/mets, Paget disease, Addison disease/acromegaly, neoplasm, Zollinger-Ellison syndrome, excessive vitamin A, excessive vitamin D, sarcoid +++ Signs and symptoms of hypercalcemia: ++ Polydipsia, polyuria, and constipation and the classic "stones, bones, abdominal groans, and psychiatric overtones" +++ EKG findings of hypercalcemia: ++ Prolonged PR interval and shortened QT interval +++ Acute treatment for hypercalcemic crisis: ++ Normal saline volume expansion with furosemide diuresis +++ Additional options for treating hypercalcemia: ++ Bisphosphonates, calcitonin, mithramycin, steroids, and dialysis +++ What kind of diuretic should be avoided in the face of hypercalcemia? ++ Thiazide diuretics (calcium-sparing diuretic) +++ Normal range for magnesium: ++ 1.5 to 2.5 mEq/L +++ Electrolyte abnormality associated with "impossible to correct" hypokalemia and hypocalcemia: ++ Hypomagnesemia +++ Name surgical causes of hypomagnesemia: ++ Aminoglycosides, diarrhea, gastric suctioning, hypocalcemia, renal failure, total parenteral nutrition (TPN), vomiting +++ Signs and symptoms of hypomagnesemia: ++ Asterixis, Chvostek sign, dysrhythmias, increased deep tendon reflexes, tachycardia, tetany, tremor, ventricular ectopy, vertigo +++ Treatment for acute hypomagnesemia: ++ IV magnesium sulfate (or magnesium chloride) +++ Treatment for chronic hypomagnesemia: ++ PO magnesium oxide +++ Name surgical causes of hypermagnesemia: ++ Iatrogenic, renal failure, TPN +++ Signs and symptoms of hypermagnesemia: ++ IV calcium, dextrose and insulin, dialysis, Lasix +++ Normal range for phosphorus: ++ 2.5 to 4.5 mg/dL +++ Critical value for phosphorus: ++ <1.0 mg/dL +++ Name surgical causes of hypophosphatemia: ++ Alcohol abuse, gastrointestinal losses, inadequate supplementation, medications, renal loss, sepsis +++ Signs and symptoms of hypophosphatemia: ++ Ataxia, cardiomyopathy, hemolysis, poor response to pressors, rhabdomyolysis, neurologic dysfunction, weakness +++ Treatment for acute hypophosphatemia: ++ IV sodium phosphate or potassium phosphate +++ Treatment for chronic hypophosphatemia: ++ PO replacement (Neutra phos) +++ Name surgical causes of hyperphosphatemia: ++ Chemotherapy, hyperthyroidism, renal failure, sepsis +++ Signs and symptoms of hyperphosphatemia: ++ Calcification, heart block +++ List the disturbances seen with tumor lysis syndrome: ++ Hypocalcemia, hyperkalemia, hyperuricemia, hyperphosphatemia +++ Name the important intracellular buffer: ++ Phosphate buffer system and proteins +++ Name the primary extracellular buffering system: ++ Bicarbonate-carbonic acid system +++ Henderson-Hasselbalch equation: ++ pH = pK + log [HCO–3]/[CO2] +++ Formula to calculate the anion gap: ++ Anion gap = Sodium – (bicarbonate + chloride) +++ Mnemonic for anion gap acidosis: ++ Mudpiles: methanol, uremia, diabetic ketoacidosis, paraldehyde, isoniazid, lactic acidosis, ethylene glycol, salicylates +++ Formula for functional excretion of sodium (FeNa): ++ FeNa = (urine sodium/urine creatinine)/(plasma sodium/plasma creatinine) +++ List some common laboratory values seen in a prerenal state: ++ BUN/Cr ratio >20, FeNa <1%, urine sodium <20, urine osmolality >500 mOsm + NUTRITION Download Section PDF Listen +++ +++ The term for the initial period during the activation of stress hypermetabolism where there is a decrease in oxygen consumption, cellular shock, and fluid imbalance lasting 24 to 36 hours: ++ Ebb phase +++ The term for the adaptation of the body to the ebb phase of stress hypermetabolism where body temperature, metabolic rate, and nitrogen loss are increased: ++ Flow phase +++ Sepsis/surgery/trauma can increase the kcal requirement by: ++ 20% to 40% +++ The percentage increase of the basal metabolic rate for every degree above 38°C: ++ 10% +++ General method to calculate the calorie requirement for a burn patient: ++ 25 kcal/kg/d + (30 kcal/d × %burn) +++ General method to calculate the protein requirement for a burn patient: ++ 1 to 1.5 g/kg/d + (3 g × %burn) +++ Level of albumin that is a strong risk factor for morbidity/mortality after surgery: ++ <3.0 g/dL +++ Pregnancy can increase the kcal requirement by: ++ 300 kcal/d +++ What fuel source does the brain use during progressive starvation? ++ Ketones +++ Most efficient form for the storage of calories: ++ Triglycerides +++ Amino acid that is the primary substrate for gluconeogenesis: ++ Alanine +++ Only amino acids to increase during stress: ++ Alanine and phenylalanine +++ Primary enzyme responsible for the transamination of amino acids (ammonia, α-ketoglutarate): ++ Glutamate dehydrogenase +++ Where does gluconeogenesis occur during late starvation? ++ Kidney +++ Name the places where glycogen is stored and the rough percentages: ++ One-third in liver and two-thirds in skeletal muscle +++ How long does it take to deplete glycogen stores during starvation? ++ 24 to 36 hours +++ List obligate glucose users in the body: ++ Adrenal medulla, peripheral nerves red blood cells, white blood cells +++ Carbohydrate digestion begins with this enzyme: ++ Salivary amylase +++ What is the protein requirement for an average healthy adult male? ++ 1 g protein/kg/d; 20% from essential amino acids +++ Protein digestion begins with this enzyme: ++ Pepsin +++ 1 g of nitrogen is contained in how many grams of protein: ++ 6.25 g of protein contains 1 g nitrogen +++ Formula to calculate the nitrogen balance: ++ (Nin – Nout) = [(protein/6.25) – (24 hour urine N + 4 g)] +++ Name the branched chain amino acids: ++ Isoleucine, leucine, valine +++ Where are branched chain amino acids metabolized? ++ Muscle +++ List the nutrients included in immune-enhancing formulas: ++ Arginine, glutamine, ω-3 fatty acids, ω-6 fatty acids +++ Where is iron absorbed? ++ Most in duodenum and some in jejunum +++ Where is Vitamin B12 (cobalamin) absorbed? ++ Terminal ileum +++ Where are bile salts absorbed? ++ Terminal ileum +++ Where are fat soluble vitamins absorbed? ++ Terminal ileum +++ Name the fat soluble vitamins: ++ Vitamin A, D, E, K +++ Where is calcium absorbed? ++ Actively in the duodenum and passively in the jejunum +++ What vitamin increased the oral absorption of iron? ++ Vitamin C +++ Fuel for colonocytes: ++ Short-chain fatty acids (butyrate) +++ Fuel for small bowel enterocytes: ++ Glutamine +++ Primary fuel for cancer cells: ++ Glutamine +++ Term for an acute form of childhood protein-energy malnutrition characterized by anorexia, edema, enlarged liver with fatty infiltrates, irritability, and ulcerating dermatoses: ++ Kwashiorkor +++ Term for severe protein-energy malnutrition characterized by energy deficiency and characterized by extensive tissue/muscle wasting and variable edema: ++ Marasmus +++ How many kcal are there in a gram of dextrose? ++ 3.4 kcal/g +++ How many kcal are there in a gram of oral carbohydrates? ++ 4 kcal/g +++ How many kcal are there in a gram of protein? ++ 4 kcal/g +++ How many kcal are there in a gram of fat? ++ 9 kcal/g +++ List metabolic complications from TPN: ++ Acid-base abnormalities Excessive glucose resulting in hyperosmolar nonketotic coma with resultant dehydration Increase in CO2 production Lipogenesis with resulting fatty liver/hepatic abnormalities +++ Maximal glucose administration for TPN delivered through a central line: ++ 3 g/kg/h +++ For an average healthy adult male, what percentage of calories should come from fat? ++ 30% +++ Rate that should not be exceeded with fat infusion: ++ 2.5 g/kg/d +++ Name an amino acid solution that contains an increased percentage of branched chain amino acids that is used in patients with encephalopathy: ++ Hepatamine 8% amino acid solution +++ The caloric value from the lipid propofol is stored in: ++ 1 kcal/cc +++ Formula to calculate the ideal body weight for a man: ++ 106 lb + 6 lb for every inch over 5 ft +++ Formula to calculate the ideal body weight for a woman: ++ 105 lb + 5 lb for every inch over 5 ft +++ List the rough percentage of calories from carbohydrates in TPN: ++ 50% to 60% +++ List the rough percentage of calories from proteins in TPN: ++ 10% to 20% +++ List the rough percentage of calories from lipids in TPN: ++ 20% to 30% +++ Electrolyte abnormalities found with refeeding syndrome: ++ Hypokalemia, hypomagnesemia, hypophosphatemia; occurs when feeding after prolonged malnutrition/starvation +++ The best parameter to check for adequate nutritional status: ++ Prealbumin +++ Half-life of retinol-binding protein: ++ ~12 hours +++ Half-life of prealbumin: ++ 2 to 3 days +++ Half-life of transferrin: ++ 8 to 9 days +++ Half-life of albumin: ++ 14 to 20 days +++ Formula for the respiratory quotient: ++ RQ = CO2 produced/O2 consumed +++ Respiratory quotient for carbohydrate: ++ 1 +++ Respiratory quotient for ethanol: ++ 0.67 +++ Respiratory quotient for fat: ++ 0.7 +++ Respiratory quotient during hyperventilation: ++ >1.1 +++ Respiratory quotient to indicate lipogenesis or overfeeding: ++ >1.0 +++ Respiratory quotient in starvation: ++ 0.6 to 0.7 (fat is fuel source during starvation) +++ Ideal respiratory quotient during mixed substrate oxidation: ++ 0.85 to 0.95 +++ Respiratory quotient <0.82 indicates: ++ Occurrence of protein oxidation; increase total energy intake by increasing carbohydrates and caloric intake +++ Respiratory quotient >1 indicates: ++ Excessive calorie load; decrease carbohydrate intake and caloric intake +++ List the effects seen with chromium deficiency: ++ Encephalopathy, hyperglycemia, neuropathy +++ List the effects seen with cobalamin (B12) deficiency: ++ Beefy tongue, megaloblastic anemia, peripheral neuropathy +++ List the effects seen with copper deficiency: ++ Pancytopenia +++ List the effects seen with essential fatty acids deficiency: ++ Dermatitis, hair loss, thrombocytopenia +++ List the effects seen with folate deficiency: ++ Glossitis, megaloblastic anemia +++ List the effects seen with niacin deficiency: ++ Diarrhea, dermatits, dementia (Pellagra) +++ List the effects seen with phosphate deficiency: ++ Encephalopathy, decreased phagocytosis, weakness +++ List the effects seen with pyridoxine (B6) deficiency: ++ Glossitis, peripheral neuropathy, sideroblastic anemia +++ List the effects seen with thiamine (B1) deficiency: ++ Cardiomyopathy, peripheral neuropathy, Wernicke encephalopathy +++ List the effects seen with zinc deficiency: ++ Hair loss, rash, poor healing +++ List the effects seen with vitamin A deficiency: ++ Night blindness +++ List the effects seen with vitamin D deficiency: ++ Rickets, osteomalacia +++ List the effects seen with vitamin E deficiency: ++ Neuropathy +++ List the effects seen with vitamin K deficiency: ++ Coagulopathy