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Revisions to the melanoma staging system were published in the seventh edition of the American Joint Committee on Cancer manual (AJCC Cancer Staging Manual) in 2009 and were implemented in January 2010.1-3 The latest TNM criteria and stage groupings are shown in Tables 12-1 and 12-2, while survival rates according to disease stage are shown in Figure 12-1. In addition, we have published updated analyses on mitotic rate, as well as the prognostic significance of patient age and the sentinel lymph node biopsy (SLNB), in determining accurate staging for clinically occult nodal metastases.4-7 This chapter incorporates material from the seventh edition of the AJCC Cancer Staging Manual published in 2009, as well as a recent book chapter, along with the updated materials published since then.1,8

TABLE 12-1

TNM Criteria for Cutaneous Melanoma (2010)a

TABLE 12-2

Anatomic Stage Groupings for Cutaneous Melanomaa

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