Skip to Main Content

We have a new app!

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more.

Download the Access App here: iOS and Android. Learn more here!


The most common indications for splenectomy are irreparable traumatic rupture and hematologic disorders. In splenic injury, nonoperative protocols result in a significant improvement in splenic salvage in both children and adults. However, in severe splenic injury, particularly in severe multisystem trauma, splenectomy is indicated. In some cases, splenic salvage is warranted. The most common hematologic disorders requiring splenectomy include immune (idiopathic) thrombocytopenic purpura, thrombotic thrombocytopenic purpura, and hereditary spherocytosis. Prior to splenectomy, clinical evaluation should be performed by an experienced hematologist and a bone marrow biopsy may be necessary to exclude unexpected bone marrow disorders not improved by splenectomy. Whereas in the past emergency splenectomy may have been occasionally needed in severe thrombocytopenia associated with hemorrhagic complications, today this is almost never needed, as nearly all patients will have improvement in platelet counts in response to steroids, intravenous immune globulin or Rho D immune globulin (winrho). Splenectomy may be indicated in cysts and tumors. Symptomatic benefit may follow splenectomy in certain other conditions, such as secondary hypersplenism, Felty’s syndrome, Banti’s syndrome, Boeck’s sarcoid, or Gaucher’s disease. In these latter patients, the surgeon should work in consultation with an experienced hematologist and medical specialists. In the past either total or partial splenectomy was indicated as part of the procedure of “staging” to determine the extent of Hodgkin’s disease. Historically stage I and II Hodgkin’s disease, traditionally, those patients who are considered candidates for primary radiation therapy, would undergo staging laparotomy (pathologic staging) to rule out definitively the presence of occult subdiaphragmatic disease. An appreciation of the risks of laparotomy and a recognition of the effectiveness of salvage chemotherapy in patients who fail primary radiation therapy have permitted the increased use of clinical staging as the basis for treatment of these patients.

Laparoscopic splenectomy is clearly the procedure of choice when technically feasible for elective splenectomy. It should be considered in all elective splenectomy cases. Relative contraindications may be considered in certain cases of previous surgery or a large spleen. Coagulopathy is not a contraindication and may actually do better with the laparoscopic approach.


It is necessary to consider the nature of the disease for which splenectomy is indicated in order to give the proper preoperative treatment. In congenital hemolytic icterus, preoperative transfusion is contraindicated, even in the presence of the most severe anemia, because of the likelihood of precipitating a hemolytic crisis. In cases of thrombocytopenic purpura, platelet transfusions may be given the morning of operation if indicated. The patient with primary splenic neutropenia, pancytopenia, or other types of hypersplenism is transfused as indicated by his general condition and the information gained from the clinical studies. Antibiotic therapy is given in the presence of neutropenia. Large amounts of blood should be available in cases of suspected traumatic rupture of the spleen, and the patient should be operated on as soon as his condition permits. Prompt splenectomy may be a ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.