Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + • Hypertrophy of normal breast tissue• Can be divided into 2 categories: 1. Pubertal hypertrophy (ages 13-17) 2. Senescent hypertrophy (older than age 50) +++ Epidemiology + • Associated with some recreational and therapeutic drugs-Marijuana-Digoxin-Thiazides-Estrogens-Phenothiazines-Theophylline +++ Symptoms and Signs + • Unilateral or bilateral breast enlargement• Mass is subareolar, smooth, firm, and discoid• Rarely painful, but patient may complain of vague breast discomfort + • Frequently no identifiable cause• Without pain, pubertal gynecomastia frequently regresses as the patient passes into adulthood• Senescent gynecomastia may also regress spontaneously• May represent local manifestation of systemic illness such as hepatic or renal insufficiency, or alterations in steroid metabolism +++ Rule Out + • Carcinoma of the breast + • History and physical exam• Observation• Biopsy of any dominant mass if concern for malignancy + • Usually left untreated• Dominant mass may be biopsied +++ Surgery +++ Indications + • Failure of enlargement to regress and breast is cosmetically unacceptable +++ Treatment Monitoring + • Follow physical exam +++ References ++Lazala C, Saenger P. Pubertal gynecomastia. J Ped Endocrinol Metab. 2002;15:553. [PubMed: 12014513] ++Daniels IR, Layer GT. Gynaecomastia. Eur J Surg. 2001;167:885. [PubMed: 11841077] Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth