Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + • Water deficit without solute deficit• Rare in surgical patients• Water deficit can be estimated from serum Na concentration• Water deficit: ((140 - serum Na) * total body water))/140 +++ Epidemiology + • Occurs in patients unable to regulate water intake• Insensible water loss from fever• Tube feedings with inadequate water content• Diabetes insipidus +++ Symptoms and Signs + • Concentrated urine• CNS depression• Lethargy• Coma• Muscle rigidity• Tremors• Spasticity• Seizures +++ Laboratory Findings + • Hypernatremia• Low urine Na despite hypernatremia + • Water deficit usually accompanied by solute (Na+) deficit + • Physical exam• Serial serum Na + • Replacement of enough water to return serum Na concentration to normal• Treat patient with D5W unless hypotension has developed in which case hypotonic saline should be used +++ Treatment Monitoring + • Serum Na +++ Prognosis + • Excellent +++ Prevention + • Adequate water intake +++ References ++Palevsky PM et al. Hypernatremia in hospitalized patients. Ann Intern Med. 1996;124:197. [PubMed: 8533994] ++Body JJ. Current and future directions in medical therapy: hypercalcemia. Cancer. 2000;88(12 Suppl):3054. Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth