Skip to Main Content
Home Books Quick Answers Surgery

Cirrhosis, Primary Biliary

Top

  • • Autoimmune disease characterized by portal tract inflammation

Symptoms and Signs

  • • Gradual increasing fatigue and pruritus

Laboratory Findings

  • • Gradual hyperbilirubinemia often evolving over 20 years

Rule Out

  • • Biliary obstruction secondary to anatomic lesion

  • • History and physical exam

    • CT abdomen

    • ERCP

    • Liver function tests

    • C-reactive protein levels

    • Anti-smooth muscle cell antibody

    • Anti-mitochondrial antibody

    • Liver biopsy

Surgery

  • • Liver transplantation

Indications

  • • Bilirubin > 10

Contraindications

  • • Medical comorbidity, active malignancy

Treatment Monitoring

  • • Bilirubin level

Complications

  • • Primary nonfunction

    • Rejection

    • Biliary leak or stricture

    • Hemorrhage

    • Hepatic artery thrombosis

Prognosis

  • • 60-70% 5-year survival following liver transplant

References

+
+
Talwalkar JA, Lindor KD. Primary biliary cirrhosis. Lancet. 2003;362:53.  [PubMed: 12853201]

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.

This site uses cookies to provide, maintain and improve your experience. MHE Privacy Center Close