Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + • Rapidly growing, painful mass of the breast• No distinct mass as tumor infiltrates breast diffusely• Name refers to clinical appearance not specific histologic subtype of mammary carcinoma +++ Epidemiology + • 3% of all breast cancer cases• Average age of diagnosis is 55• Rarely occurs in men or children• No predisposition conferred by pregnancy or lactation +++ Symptoms and Signs + • Breast mass• Erythematous, edematous, warm skin on breast• Failure to respond to antibiotics (if initially diagnosed as breast cellulitis) within 1-2 weeks• Peau d'orange changes, most notable over dependent portions of the breast +++ Laboratory Findings + • Biopsy shows invasion of subdermal lymphatics +++ Imaging Findings + • Mammography can demonstrate a mass, stromal coarsening, increased parenchymal density, or skin thickening + • Metastases tend to occur early and widely• Skin changes may precede palpable breast mass• Tumors are more likely to be estrogen receptor negative compared with tumors that do not have an inflammatory component +++ Rule Out + • Mastitis/breast abscess + • Complete history (including family and reproductive) and physical exam• Bilateral mammography• Breast biopsy + • Rarely curable• Mastectomy rarely indicated alone• Multimodal therapy with radiation, chemotherapy, and hormonal therapy +++ Surgery +++ Indications + • Mastectomy for local control of disease +++ Medications + • Anthracycline-based combination chemotherapy• External beam radiation +++ Treatment Monitoring + • Self breast exams• Semiannual clinical breast exam• Annual bilateral mammogram +++ Complications + • Edema of the arm• Metastatic spread• Local chest wall involvement +++ Prognosis + • Rarely curable as metastases occur early and widely• 5-year survival about 50% +++ References ++Barni S et al: Locally advanced breast cancer. Curr Opin Obstet Gynecol 2006;18:47. [PubMed: 16493260] ++Cristofanilli M et al: Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique disease. Cancer 2007;110:1436. [PubMed: 17694554] ++Dawood S et al: What progress have we made in managing inflammatory breast cancer? Oncology (Williston Park) 2007;21:673. [PubMed: 17564325] +++ Practice Guidelines + • The National Comprehensive Cancer Networkhttp://www.nccn.org/ Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth