Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content + • Acute hyperventilation lowers Paco2 without concomitant changes in plasma bicarbonate concentration• Chronic respiratory alkalosis occurs in pulmonary and liver disease +++ Epidemiology + • May be early sign of sepsis +++ Symptoms and Signs + • Paresthesias• Carpopedal spasm• Positive Chvostek sign + • Electrolyte pattern of chronic respiratory alkalosis is the same as hyperchloremic acidosis; they can only be distinguished by ABG pH measurement + • ABG measurement• Serum electrolytes + • Chronic respiratory alkalosis does not generally require treatment +++ Complications + • Treatment of chronic respiratory alkalosis may lead to metabolic acidosis and hyperchloremia +++ References ++Adrogue HJ et al. Management of life-threatening acid-base disorders. (Two parts.) N Engl J Med. 1998;338:26, 107. ++Krapf R et al: Chronic respiratory alkalosis. The effect of sustained hyperventilation on renal regulation of acid-base equilibrium. N Engl J Med 1991;324:1394. [PubMed: 1902283] Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth