Most cases of NMS have been associated with high-potency neuroleptics such as haloperidol and thiothixene. However, the list of potential triggers includes butyrophenones (e.g., haloperidol), phenothiazines (e.g., chlorpromazine and fluphenazine), thioxanthenes (e.g., thiothixene), dopamine-depleting agents (e.g., tetrabenazine), dibenzoxazepines (e.g., loxapine), and withdrawal of levodopa/carbidopa or amantadine. The newer atypical antipsychotic drugs such as clozapine, risperidone, olanzapine, ziprasidone and quetiapine have also been reported to induce NMS. NMS can be associated with antiemetics (prochlorperazine), peristaltic agents (metoclopramide), anesthetics (droperidol), and sedatives (promethazine).32 Rechallenge with the inciting drug may not result in recurrence of NMS. Other factors suggested to contribute to the development of NMS include lithium therapy, ambient heat, dehydration, psychomotor agitation, and underlying brain injury.33,34