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Test Taking Tip
Hematology requires lots of memorization. Important topics to look over include bleeding disorders and the various anticoagulants. These are basic questions you don’t want to miss.
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THE COAGULATION PATHWAY
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Sequence of the intrinsic pathway of coagulation:
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Prekallikrein + HMW kininogen + factor XII + exposed collagen → activates factor XI → activates factor IX, combines with factor VIII → activates factor X, combines with factor V → converts prothrombin (factor II) into thrombin. Thrombin converts fibrinogen into fibrin.
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Sequence of the extrinsic pathway of coagulation:
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Which factor is the convergence point and common to both the extrinsic and intrinsic pathways of coagulation?
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What does the prothrombin complex consist of?
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What function does thrombin have?
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Which factor has the shortest half-life?
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What factor can be used to differentiate a consumptive coagulopathy from hepatocellular disease?
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Which factors are known as the labile factors (activity lost in stored blood)?
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What function does factor XIII have?
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What does protein C do?
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What does protein S do?
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What does Von Willebrand factor (vWF) do?
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What is the function of antithrombin III?
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Binds heparin, inhibits factors IX, X, XI, and thrombin
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Where does tissue plasminogen activator come from, and what does it do?
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