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Test Taking Tips
Topics related to transplant are usually memorization-based.
Quickly review transplant medications and the types of rejection the night before the test.
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Name the cells of origin and functions of the following interleukins:
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Mononuclear phagocytes, T and B cells, NK, cells fibroblasts, neutrophils, smooth muscle cells
Proliferation of T and B cells; fever, inflammation; endothelial cell activation; increases liver protein synthesis
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Mononuclear phagocytes, T cells, endothelial cells
B-cell proliferation/differentiation; T-cell activation; increases liver acute phase reactants; fever, inflammation
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Lymphocytes, monocytes, multiple other cell types
Stimulates granulocyte activity, chemotactic activity; potent angiogenic factor
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Mononuclear phagocyte, T cells
B-cell activation/differentiation, inhibition, mononuclear phagocytes
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Mononuclear phagocytes, dendritic cells
IFN-γ synthesis, T-cell cytolytic function, CD4+ T-cell differentiation
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INTERFERONS AND OTHER CHEMOKINES
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What cells produce interferon-γ and what are its functions?
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NK and T cells
Increases expression of class I and class II MHC, activates macrophages and endothelial cells, augments NK activity, antiviral
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What cells produce interferon-α, β and what are their functions?
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Mononuclear phagocyte-α; fibroblast-β
Mononuclear phagocyte increases class I MHC expression, antiviral, NK-cell activation
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What cells produce tumor necrosis factor-α, β and what are their functions?
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NK and T cells, mononuclear phagocyte
B-cell growth/differentiation, enhances T-cell function, macrophage activator, neutrophil activator
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What cells produce transforming growth factor-β and what are its functions?
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What cells produce lymphotoxin and what are its functions?
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What was the first effective clinical immunosuppressive regimen for the transplantation of solid organs? (It was introduced in 1962.)
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What are the 2 commercially available antilymphocyte globulins used for induction immediately after transplantation?
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What may be seen with the first or ...