Test Taking Tips
Topics related to transplant are usually memorization-based.
Quickly review transplant medications and the types of rejection the night before the test.
Name the cells of origin and functions of the following interleukins:
Mononuclear phagocytes, T and B cells, NK, cells fibroblasts, neutrophils, smooth muscle cells
Proliferation of T and B cells; fever, inflammation; endothelial cell activation; increases liver protein synthesis
Mononuclear phagocytes, T cells, endothelial cells
B-cell proliferation/differentiation; T-cell activation; increases liver acute phase reactants; fever, inflammation
Lymphocytes, monocytes, multiple other cell types
Stimulates granulocyte activity, chemotactic activity; potent angiogenic factor
Mononuclear phagocyte, T cells
B-cell activation/differentiation, inhibition, mononuclear phagocytes
Mononuclear phagocytes, dendritic cells
IFN-γ synthesis, T-cell cytolytic function, CD4+ T-cell differentiation
INTERFERONS AND OTHER CHEMOKINES
What cells produce interferon-γ and what are its functions?
NK and T cells
Increases expression of class I and class II MHC, activates macrophages and endothelial cells, augments NK activity, antiviral
What cells produce interferon-α, β and what are their functions?
Mononuclear phagocyte-α; fibroblast-β
Mononuclear phagocyte increases class I MHC expression, antiviral, NK-cell activation
What cells produce tumor necrosis factor-α, β and what are their functions?
NK and T cells, mononuclear phagocyte
B-cell growth/differentiation, enhances T-cell function, macrophage activator, neutrophil activator
What cells produce transforming growth factor-β and what are its functions?
What cells produce lymphotoxin and what are its functions?
What was the first effective clinical immunosuppressive regimen for the transplantation of solid organs? (It was introduced in 1962.)
What are the 2 commercially available antilymphocyte globulins used for induction immediately after transplantation?