Test Taking Tips
The most commonly tested mechanism of actions of drugs are succinylcholine (vs other paralytics), imatinib, fluoroquinolones, warfarin, and corticosteroids. Don't over-memorize intricate details of exotic drug classes.
What are some basic drug properties?
What is first-order kinetics?
What is zero-order kinetics?
What is the primary role of the P450 system?
What are some of the inducers of the P450 system?
Cigarette smoke, phenobarbital, rifampin, ethanol, INH, phenytoin, etc
What are some of the inhibitors of the P450 system?
Grapefruit, erythromycin, nelfinavir, itraconazole, etc
Drug administration by continuous intravenous infusion (upper panel) or intermittent intravenous bolus (lower panel). Attainment of steady-state plasma concentration (Cpss) occurs after 3 to 5 half-lives, regardless of the dosing regimen. Peak and trough fluctuations around Cpss are aimed to each be within the therapeutic range (therapeutic but subtoxic plasma levels). (Reproduced from Hall JB, Schmidt GA, Wood LDH. Principles of Critical Care. 3rd ed. http://www.accessmedicine.com. Copyright © The McGraw-Hill Companies, Inc. All rights reserved.)
What is half-life of a drug?
What is a Phase I reaction?
What is a Phase II reaction?
Synthetic reaction, for example, conjugation, methylation, sulfation, etc
What are some treatments for achalasia?
What is the management for esophageal varices bleeding?
What are some treatment options for reflux disease?
Selective H2 blockers (cimetidine, ranitidine, etc) = 24-hour acid reduction by 70%.
Proton pump inhibitors (pantoprazole, omeprazole, etc) = 10% rebound hyperacidity after discontinuing due to hypergastrinemia
What are the D2 agonists motility agents and how do they work?
Domperidone and metoclopramide, they increase lower esophageal sphincter (LES) tone, increase antrum contraction, increase small bowel peristalsis (beware of extrapyramidal symptoms ...