RT Book, Section A1 Meric-Bernstam, Funda A1 Pollock, Raphael E. A2 Brunicardi, F. Charles A2 Andersen, Dana K. A2 Billiar, Timothy R. A2 Dunn, David L. A2 Hunter, John G. A2 Matthews, Jeffrey B. A2 Pollock, Raphael E. SR Print(0) ID 1117742106 T1 Oncology T2 Schwartz's Principles of Surgery, 10e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071796743 LK accesssurgery.mhmedical.com/content.aspx?aid=1117742106 RD 2024/04/25 AB Modern cancer therapy is multidisciplinary, involving coordinated care by surgeons, medical oncologists, radiation oncologists, reconstructive surgeons, pathologists, radiologists, and primary care physicians.Understanding cancer biology is essential to successfully implement personalized cancer therapy.The following alterations are critical for malignant cancer growth: self-sufficiency of growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, potential for limitless replication, angiogenesis, invasion and metastasis. Reprogramming of energy metabolism and evading immune destruction.