RT Book, Section A1 Doherty, Gerard M. SR Print(0) ID 58113034 T1 Hirschsprung Disease T2 Quick Answers Surgery YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN LK accesssurgery.mhmedical.com/content.aspx?aid=58113034 RD 2024/04/19 AB • Distal colon aganglionosis resulting in dysfunctional myenteric plexus• Associated cardiac defects in 2-5%• Trisomy 21 in 5-15%• Occasionally preceded by neonatal appendicitis or meconium plug syndrome• 50% of cases diagnosed in neonates, almost 50% of cases diagnosed in children younger than 2, and rarely in older children or adults