RT Book, Section A1 Untch, Michael A1 Minckwitz, Gunter von A2 Kuerer, Henry M. SR Print(0) ID 6413437 T1 Chapter 48. The German Experience: Primary Systemic Therapy with Cytotoxic Agents T2 Kuerer's Breast Surgical Oncology YR 2010 FD 2010 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160178-8 LK accesssurgery.mhmedical.com/content.aspx?aid=6413437 RD 2024/04/20 AB The success of preoperative, neoadjuvant chemotherapy for locally advanced and inflammatory breast cancer, combined with emerging data on the use of adjuvant chemotherapy, led to the evaluation of the primary systemic therapy (PST) (neoadjuvant) approach for women with primary operable breast cancer. Potential advantages of PST include increasing rates of breast conservation, reducing mortality with lower toxicity, and in vivo testing of sensitivity of cancer cells to the systemic therapy used.1