RT Book, Section
A1 Mamounas, Eleftherios P.
A1 Wickerham, D. Lawrence
A1 Fisher, Bernard
A1 Geyer, Charles E.
A1 Julian, Thomas B.
A1 Wolmark, Norman
A2 Kuerer, Henry M.
SR Print(0)
ID 6412358
T1 Chapter 42. The NSABP Experience
T2 Kuerer's Breast Surgical Oncology
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160178-8
LK accesssurgery.mhmedical.com/content.aspx?aid=6412358
RD 2024/04/20
AB Over  the  past  50  years,  the  National  Surgical  Adjuvant  Breast  and  Bowel  Project  (NSABP)  has  made  significant  contributions  in  reducing  the  extent  of  surgical  resection  and  in  improving  the  outcome  of  patients  with  early-stage  breast  cancer  through  the  conduct  of  large,  randomized  clinical  trials  evaluating  various  aspects  of  local  and  systemic  therapy.  Some  of  these  trials  have  been  instrumental  in  establishing  new  standards  of  care  in  the  locoregional  and  adjuvant  systemic  therapy  for  these  patients.  The  rationale,  design,  and  updated  results  from  those  pivotal  trials  are  reviewed  in  this  chapter.  In  addition,  the  design  and  rationale  for  newer  trials  put  forth  by  the  NSABP  and  other  major  cooperative  groups  in  an  attempt  to  refine  several  aspects  of  adjuvant  therapy  and  introduce  new  promising  drugs  are  also  reviewed.  Finally,  current  and  future  research  directions  of  the  NSABP  in  the  context  of  other  developments  in  the  surgical  and  adjuvant  breast  cancer  therapy  are  discussed.