RT Book, Section
A1 Arora, Nimmi
A1 Simmons, Rache M.
A2 Kuerer, Henry M.
SR Print(0)
ID 6409032
T1 Chapter 19. Paget Disease of the Breast
T2 Kuerer's Breast Surgical Oncology
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160178-8
LK accesssurgery.mhmedical.com/content.aspx?aid=6409032
RD 2024/04/19
AB An  English  surgeon  by  the  name  of  Sir  James  Paget  reported  on  a  condition  of  eczematous  change  of  the  nipple–areola  complex  associated  with  underlying  breast  malignancy  in  1874.1  It  is  now  recognized  that  Paget  disease  denotes  an  entity  of  intraepithelial  adenocarcinoma  within  the  epidermis  of  the  nipple–areola  complex  that  is  associated  with  underlying  in  situ  or  invasive  mammary  carcinoma  in  92%  to  100%  of  cases.2-4  Paget  cells,  large  cells  with  pale  cytoplasm  and  prominent  nucleoli,  identified  within  nipple  epidermis  on  histology  confirm  diagnosis.  Ninety  percent  of  these  will  overexpress  Her-2/neu.