RT Book, Section A1 Zenga, Joseph A1 Lin, Derrick T. A1 Deschler, Daniel G. A2 Lalwani, Anil K. SR Print(0) ID 1169075953 T1 Neck Masses T2 Current Diagnosis & Treatment Otolaryngology—Head and Neck Surgery, 4e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9780071847643 LK accesssurgery.mhmedical.com/content.aspx?aid=1169075953 RD 2024/04/19 AB ESSENTIALS OF DIAGNOSISThe differential diagnosis of a neck mass is primarily guided by anatomic location, physical characteristics of the mass, and patient age.Due to ease of acquisition, relative low cost, and 3-dimensional detail, computed tomography (CT) scan is the initial imaging modality of choice in the majority of adult neck masses.Fine-needle aspiration (FNA) biopsy is the preferred approach to obtain diagnostic tissue in most neck masses.Core biopsy should be considered when FNA is insufficient and excisional or incisional biopsy performed only in carefully evaluated and selected cases.Human papillomavirus (HPV)-associated squamous cell carcinoma (SCC) must be considered and ruled out in any adult cystic neck mass.