RT Book, Section A1 Lebastchi, Amir H. A1 Callender, Glenda G. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145765162 T1 Natural History and Principles of Management of Pancreatic Neuroendocrine Tumors T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK accesssurgery.mhmedical.com/content.aspx?aid=1145765162 RD 2024/04/19 AB Pancreatic neuroendocrine tumors (PNETs) are tumors that originate from the islet cells of the pancreas and are also often referred to as islet cell tumors. With an estimated incidence of about 2.5 to 5 per 100,000 persons per year, these uncommon tumors represent only 1% to 2% of pancreatic malignancies.1 In contrast to pancreatic adenocarcinoma, the incidence of PNETs appears to have increased over the past decades.2,3 Autopsy studies have shown that small, asymptomatic PNETs may occur in as many as 10% of people.4,5 Thus, increased detection, particularly because of increased imaging and advances in imaging technology, may account for much of the rise in the incidence of PNETs.6-8