RT Book, Section
A1 Sandulache, Vlad C.
A1 Skinner, Heath D.
A1 Kupferman, Michael E.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145759170
T1 Tumors of the Salivary Glands
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK accesssurgery.mhmedical.com/content.aspx?aid=1145759170
RD 2024/04/24
AB Salivary  gland  (SG)  tumors  are  rare  neoplasms  of  the  neck  and  head  which  can  occur  in  the  paired  major  salivary  glands  or  in  one  of  the  hundreds  of  minor  salivary  glands  distributed  throughout  the  oral  cavity  and  pharynx.  Benign  neoplasms  are  slow  growing,  amenable  to  surgical  cure,  and  if  appropriately  excised  recur  with  a  low  frequency.  Malignant  tumors  can  arise  from  any  one  of  the  cellular  components  of  the  SG.  They  are  generally  faster  growing  compared  to  their  benign  counterparts  and  often  invade  into  adjacent  structures.  A  subset  of  malignant  tumors  display  substantial  predilection  for  nerve  invasion  which  can  lead  to  increased  patient  morbidity  and  a  lower  rate  of  surgical  cure.  For  high-grade  histologies  clinical  outcomes  remain  poor  and  multimodality  treatment  strategies  are  employed  at  most  centers.1-5  Due  to  the  rarity  of  each  specific  malignant  histology,  there  is  a  dearth  of  prospective  clinical  trial  data,  which  limits  our  understanding  of  disease  progression  and  the  effects  of  specific  surgical  and  nonsurgical  interventions.  A  more  detailed  molecular  characterization  of  SG  cancers  may  shed  additional  light  on  the  pathogenesis  of  this  disease  process  and  provide  novel  therapeutic  interventions  in  the  future.