RT Book, Section
A1 Gottlieb, Danielle
A1 Mayer, John E.
A2 Cohn, Lawrence H.
A2 Adams, David H.
SR Print(0)
ID 1144168711
T1 Tissue Engineering for Cardiac Valve Surgery
T2 Cardiac Surgery in the Adult, 5e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071844871
LK accesssurgery.mhmedical.com/content.aspx?aid=1144168711
RD 2024/04/20
AB Tissue  engineering  is  a  developing  science,  comprising  elements  of  engineering  and  biology,  whose  aim  is  to  build  replacement  tissues  de  novo,  from  individual  cellular  and  structural  components.  The  impetus  for  our  work  on  tissue-engineered  cardiovascular  structures  arises  from  the  need  to  replace  cardiovascular  tissues  that  failed  to  develop  normally  during  embryogenesis  or  have  become  dysfunctional  as  a  consequence  of  disease.  In  pediatric  patients,  the  cardiovascular  structures  most  often  afflicted  by  congenital  anomalies  involve  the  cardiac  valves  and  great  vessels,  and  the  theoretical  advantages  of  a  tissue-engineered  structure  containing  live  cells  are  the  ability  to  grow,  remodel,  and  repair.  Although  growth  potential  is  not  a  consideration  for  the  adult  population,  durability  of  valve  structures  remains  an  important  issue  for  bioprosthetic  valves,  and  a  tissue  engineering  approach  offers  the  potential  to  improve  durability  by  providing  the  repair  and  remodeling  capability.