RT Book, Section A1 Thompson, Callie M. A1 O’Keefe, Grant E. A2 Moore, Ernest E. A2 Feliciano, David V. A2 Mattox, Kenneth L. SR Print(0) ID 1141191765 T1 Genomics and Acute Care Surgery T2 Trauma, 8e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071847292 LK accesssurgery.mhmedical.com/content.aspx?aid=1141191765 RD 2024/04/19 AB Outcomes after traumatic injury, perhaps more than in any other surgical disease, have improved through standardization of care. Nevertheless and despite seemingly ideal care, unexpected outcomes occur. Why do patients with similar injuries or severity of acute illness, despite receiving comparable and appropriate treatment, often follow different paths? While one patient recovers uneventfully from massive transfusion for hemorrhagic shock after a motor vehicle collision, another follows a prolonged course complicated by nosocomial pneumonia and organ failure. Consider also, the seemingly more straightforward task of preventing or treating deep venous thromboembolic disease. Despite our understanding of the biology of coagulation and pharmacotherapeutic strategies, venous thromboses and pulmonary emboli still occur, often with fatal consequences.