TY - CHAP M1 - Book, Section TI - Chapter 35. Chronic Kidney Disease & Renal Replacement Therapy A1 - Lee, Brian K. A1 - Vincenti, Flavio G. A2 - McAninch, Jack W. A2 - Lue, Tom F. PY - 2013 T2 - Smith & Tanagho's General Urology, 18e AB - In chronic kidney disease (CKD), reduced clearance of certain solutes principally excreted by the kidney results in their retention in the body fluids. The solutes are end products of endogenous metabolism as well as exogenous substances (eg, drugs). The most commonly measured indicators of renal failure are blood urea nitrogen and serum creatinine. The renal clearance of creatinine (as calculated from a 24-hour urine collection) is often used as a surrogate measure of glomerular filtration rate (GFR). SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accesssurgery.mhmedical.com/content.aspx?aid=56949413 ER -