• Splenic involvement (splenomegaly and hypersplenism) due to infiltration of lymphocytes or mast cells or initiation of extramedullary hematopeosis
• Splenomegaly and hypersplenism, resulting in anemia, thrombocytopenia, and/or neutropenia
• Splenectomy may be indicated for hypersplenism, for diagnosis, or for primary surgical removal of the predominant or only site of disease
Chronic Lymphocytic Leukemia (CLL)
Hairy Cell Leukemia (HCL)
• Leukocytosis or leukopenia
• Thrombocytosis or thrombocytopenia
• Leukoerythroblastic peripheral smear with teardrop poikilocytosis
• Giant abnormal platelets
• Pain over the spleen from splenic infarcts is common
• Portal hypertension develops in some cases as a result of fibrosis of the liver, greatly increased splenic blood flow, or both
• Other causes of hypersplenism and cytopenias (Waldenstrom macroglobulinemia, non-Hodgkin lymphoma, Hodgkin disease, chronic myelogenous leukemia)
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