• A malignant neoplasm that originates in lymphoid tissue
• Characterized histologically by the presence of Reed-Sternberg cells
• Develops in lymph nodes and spreads in an orderly fashion to contiguous lymph node beds
• Several histologic subtypes exist based on lymphocyte infiltration:
• Most important prognostic factor is the disease stage
• Imaging findings are specific to the location and stage
• Chest film: May demonstrate mediastinal adenopathy
• CT scan is the main staging tool used to demonstrate contiguous areas of adenopathy
• Detailed history; ask about risk factors and presence of constitutional B-symptoms
• Thorough physical exam assessing all lymph node beds
• Routine laboratory testing
• Excisional biopsy of enlarged lymph node
• Bone marrow biopsy
• CT scans of the neck, chest, abdomen, and pelvis
• Excisional lymph node biopsy to establish diagnosis
• Rarely, a staging laparotomy is necessary if the anatomic extent of disease in the abdomen is important in guiding therapy
• Physical exam to evaluate for lymphadenopathy
• Radiographic evaluation as clinically indicated (eg, with the re-development of constitutional "B" symptoms)
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