The City of Hope (COH), an NCI-designated Comprehensive Cancer Center in Southern California, established the Division of Clinical Cancer Genetics and the Cancer Screening & Prevention Program (CSPP) in late 1996 as components of a multidisciplinary clinical and research program to assess individuals and families at increased cancer risk.22 The initial clinical CSPP program, established to provide comprehensive GCRA services, was jointly developed by an MD with expertise in both medical oncology and clinical genetics, and an APN with genetic expertise. Subsequent personnel include a clinic coordinator, a laboratory research associate to conduct studies under the principal investigator's supervision and manage biospecimens from an IRB-approved Hereditary Cancer Registry protocol; a certified clinic research associate to organize the registry's relational database and pedigree drawing program27 and assist in conducting clinical protocols; and dedicated administrative support staff, another oncologist, 3 board-certified genetic counselors, a project coordinator, 3 assistants, and an education assistant, all partly funded by research and education grants. Cancer center resources include a community health education specialist, research psychologists, and doctoral nurse scientists with expertise in education, quality of life, and survivorship research. Extramural consultants in public health and law help to support cancer genetics research in ethical, legal, and social issues. Grant support also enabled an underserved, primarily Hispanic, community outreach GCRA program. Educational outreach via CME-accredited cancer genetics presentations at regional medical centers increased the number and appropriateness of referrals.28 A weekly multidisciplinary Clinical Cancer Genetics Working Group with experts in medical and surgical oncology, clinical genetics, genetic counseling, and clinical research allows for consensus on pedigree analysis, mutation probability, testing strategies, test results interpretation, medical management advice, and identification of candidates for research studies.