Chapter 69

When treating patients with non-small cell lung cancer (NSCLC), it is important to assign an accurate clinical or pathologic stage to the disease at the time of diagnosis. This adds value to the process of selecting the most appropriate therapy for the individual patient, whether surgical resection, neoadjuvant chemotherapy or radiotherapy, or definitive chemoradiation. The current cancer staging convention uses the basic descriptors originally proposed by Denoix: primary tumor (T), lymph node involvement (N), and tumor metastasis (M).1 The contemporary classification system was adopted worldwide in 1997 after features of the 1986 combined American Joint Committee on Cancer and the International Union Against Cancer TNM staging system2 were reconciled with the 1983 American Thoracic Society statement on cancer staging. The organization responsible for updating this system is the International Association for Lung Cancer Staging. The value of classifying NSCLC patients according to a uniform staging system that has prognostic implications based on stage grouping is difficult to overstate.

Clinical staging can be determined based on CT scanning, MRI, and CT/PET scanning. Pathologic staging requires biopsy, which can be obtained from cervical or anterior mediastinoscopy, during video-assisted thoracic surgery (VATS) approaches, less commonly by means of open thoracotomy, and most recently by fine-needle aspiration performed during endoscopic or endobronchial ultrasound. Lymph node involvement has important implications for surgical treatment strategies for lung cancer.4–6 Patients without lymph node involvement (N0) or those with limited involvement (N1), which is usually determined at the time of surgery, are candidates for resection based on T and M status. Most patients with contralateral or supraclavicular disease (N3) or T4 involvement are not resectable (stage IIIB). The usual approach in stage IIIA patients with ipsilateral mediastinal nodal involvement (N2) involves either neoadjuvant chemotherapy or chemoradiation, followed by resection, if appropriate, when N2 status is determined prior to resection. In some cases, surgically detected N2 disease can be discovered at the time of resection by means of lymph node dissection in conjunction with the pulmonary resection. There is no doubt that sampling of lymph nodes in some fashion is useful for staging and prognostic purposes. However, the extent of lymph node dissection is controversial, and the benefits of systematic sampling versus complete mediastinal lymph node dissection or extended lymph node dissection are still under review.7–10

To unify the two most widely used systems of lymph node mapping in NSCLC, the American Joint Committee on Cancer and the International Union Against Cancer adopted a standardized method of classifying lymph node stations in 1996. This was outlined in 1997 by Mountain and Dresler based on the work of Naruke and the American Thoracic Society and the North American Lung Cancer Study Group.11 The most notable difference between these systems was the boundary between peribronchial hilar (N1) and paratracheal mediastinal (N2) lymph nodes comprising stations 4 and 10, respectively. These are now ...

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

## Subscription Options

### AccessSurgery Full Site: One-Year Subscription

Connect to the full suite of AccessSurgery content and resources including more than 160 instructional videos, 16,000+ high-quality images, interactive board review, 20+ textbooks, and more.