• 1% of all breast cancers
• No age group predilection
• Changes may be limited to the nipple, extend to the areola, or to the skin around the areola
• 50–60% have a palpable tumor
• If lesion is confined to nipple only, axillary metastases present in only 5% of patients
• Paget disease of the breast has been associated with breast carcinoma developing in males who had Klinefelter syndrome
• Burning and pruritus of the nipple
• Superficial erosion or ulceration of the nipple
• Serous or bloody nipple discharge
• Nipple retraction
• Edema of the arm
• Metastatic spread
• Disease is manifestation of mammary carcinoma, and thus prognosis is determined by extent of associated carcinoma
• No underlying mass and treated by modified radical mastectomy, 10-year survival is 82–100%
• Palpable invasive tumor, but node negative, treated with modified radical mastectomy, 10-year survival is 70%
Chen CY et al: Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S. Cancer
• Also known as osteitis deformans
• Nonmalignant disease involving accelerated bone resumption followed by deposition of dense, disorganized, and ineffectively mineralized bone matrix
• Etiology is unknown, although posited to be infectious; hereditary causes possible as well
• 3 phases of disease:
–Intense bone resorption
–Production of abundant woven bone with ineffective mineralization
–Deposition of sclerotic, chaotic cortical and trabecular bone
• Second most common bone disorder, behind osteoporosis
• Male:female ratio is 1:1
• Affects 3% of persons in the United States
• Affects 10% of persons older than ...
Log In to View More
If you don't have a subscription, please view our individual subscription options below to find out how you can gain access to this content.
Want remote access to your institution's subscription?
Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.
If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.
AccessSurgery Full Site: One-Year Subscription
Connect to the full suite of AccessSurgery content and resources including more than 160 instructional videos, 16,000+ high-quality images, interactive board review, 20+ textbooks, and more.
Pay Per View: Timed Access to all of AccessSurgery
24 Hour Subscription $34.95
48 Hour Subscription $54.95
Pop-up div Successfully Displayed
This div only appears when the trigger link is hovered over.
Otherwise it is hidden from view.