• Most common form of thyroiditis
• 0.3 to 1.5 cases per 1000 population per year; 10–15 times more common in women
• Approximately 15% of women are affected in the United States; majority are 30–50 years of age
• Enlarged, occasionally tender, thyroid
• Atrophic stage, shrunken, firm thyroid
• Elevated thyroid-stimulating hormone (TSH)
• Decreased tri-iodothyronine (T3) and thyroxine (T4
• Elevated titers of antimicrosomal and antithyroglobulin antibodies
• Patient may have other associated autoimmune conditions
• Associated with HLA-DR3, HLA-DR5, and HLA-B8
• Thyroid neoplasia should be ruled out in the setting of asymmetry or cervical lymphadenopathy
• Thyroid lymphoma
• Thyroid carcinoma
• History and physical exam
• Serum thyroid function tests and thyroglobulin and microsomal antibody titers
• Needle biopsy if concerned about malignancy
Kon YC, DeGroot LJ: Painful Hashimotoâs thyroiditis as an indication for thyroidectomy: clinical characteristics and outcome in seven patients. J Clin Endocrinol Metab
Mezosi E et al: Aberrant apoptosis in thyroid epithelial cells from goiter nodules. J Clin Endocrinol Metab
• Curable in 80% of cases when detected at an early stage
• Most patients present with locoregional spread
• Most important causative agents are tobacco and alcohol
• A lesion that appears 3 years after a previous cancer is considered a new primary cancer
• Potential sites include:
–False vocal cords
–External auditory canal
• Approximately 47560 new cases and 11260 deaths in the US in 2008 for Oral Cavity, Pharynx and Larynx.
• Tobacco and alcohol account for 75% of oral, oropharyngeal, and hypopharyngeal cancers
• Cigarrette smoking causes 80% of laryngeal cancers...
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